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Description

Am J Physiol Regul Integr Comp Physiol (2016) 310(10):R88595

Research status FDA-approved for HIV lipodystrophy

Juul A, Andersson AM, Pedersen SA, et al

Together these modifications dramatically reduce binding to IGF-binding proteins (IGFBPs), extending the free fraction half-life from approximately 10-15 minutes for native IGF-1 to roughly 20-30 hours for IGF-1 LR3