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In a single center study, the incidence of calciphylaxis in patients receiving dialysis was 4.5% per year with a 6-month mortality rate of 33% in patients presenting with plaques only, but surged above 80% if ulceration was present (Fine and Zacharias, Kidney Int 2022)

In addition, the major mechanisms proposed to date are based on experimental models and few clinical studies, which have small sample sizes and uncontrolled designs

Zhang, X.-Q

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Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors