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Beyond acting as carriers, certain metal-based NPs exhibit intrinsic anti-inflammatory activity and can function as therapeutic agents without encapsulating additional drugs or requiring external stimuli such as heat, magnetic fields, or light [40]

The increased IGF-1 in muscles of piglets and mice resulted in the alteration of its downstream substances, including phosphorylated/total AKT ratio and genes related to myofibrillar synthesis ( MyHCI , MyHCIIa , MyHCIIx , and MyHCIIb ) and differentiation ( Myogenin and MyoD ) (Fig

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157 While corticosteroids and other immunosuppressive agents exert broad anti-inflammatory effects, direct inhibition of NLRP3 inflammasome activation represents a more specific therapeutic strategy, potentially allowing for more effective suppression of inflammation with reduced off-target effects