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Journal of Natural Medicines, 63 (3), 274-282

Toxicology Silymarin has been known for its very low toxicity, but the picture has recently been enlarged by an important chronic toxicity study which added some new data on neoplasias

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when symptoms do appear, they often include weight changes, rapid heartbeat, and signs of thyrotoxicosis

Studies have shown that reductions in CSF ferritin following antioxidant therapy (e.g., N-acetylcysteine) or iron chelation (e.g., deferoxamine) correlate positively with improvements in cognitive performance, supporting their use as dynamic indicators of clinical efficacy (Du et al., 2024)