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Frontiers in Oncology , 12 , 887257 Gotvaldov, K., pakov, J., Novotn, J., Baslarov, K., Jeek, P., Rossmeislov, L., Gojda, J., & Smolkov, K

Researchers should consult the primary literature and follow institutional protocols, including appropriate handling given copper's toxicity profile at higher concentrations

These findings collectively suggest that low-dose sirolimus possesses a favorable risk-benefit ratio in RA patients across varying disease activity states, supporting its potential as an immunomodulatory adjunct in RA management