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[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Gonca E., Darici F

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But now it's exactly the reverse." Another possible target for modulating microglial activity is the complement system, a signaling pathway that can tag molecular danger signalsor mistakenly, synapsesfor microglia to consume

Combination therapies, such as Miltefosine with Paromomycin or liposomal Amphotericin B, are also being investigated to improve effectiveness and reduce treatment duration ( Nanoparticle formulations of Amphotericin B, including topical options, are being trialed for safer, localized treatment of CL lesions ( 7 Emerging drug targets in Leishmania Recent advances in molecular and cellular biology have identified several promising drug targets that could pave the way for novel therapeutic interventions ( Leishmania parasites, suggesting its potential as a therapeutic target for visceral leishmaniasis (Wyllie et al., 2018)

The prognosis of patients with HF is generally poor (Zhang et al., 2017)