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The OIS phenomenon, however, may be the rationale for the lack of progression of PA to higher-grade tumors, in the absence of additional cooperating mutations (59)

Pyruvic acid production from alanine and lactate can also occur in the mitochondrial matrix

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In three studies of mild asthmatics and healthy controls, no differences in glutathione peroxidase activity in airway cells or bronchoalveolar lavage fluid were observed at baseline (52, 62, 300) or after allergen challenge (52) despite significant differences in superoxide dismutase activity between groups