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Monoclonal antibodies (bNAbs) are another type of entry inhibitor

Plasmacytoid dendritic cell activation and IFN- production are prominent features of murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis

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Clinical data underscore this limitation, showing that while PD-1/PD-L1 blockade induces profound responses in a subset of patients, durable benefit is restricted to a minority of patients [79]

A large number of enzymes that participated in cytosolic glycolysis, gluconeogenesis, the urea cycle, nitrogen metabolism, glycogen metabolism, mitochondrial fatty acid oxidation, the TCA cycle and amino acid catabolism can be regulated by sirtuins