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These data are in agreement with earlier studies, where the turnover of polyP demonstrated dependence on the metabolic activity of cells examined (Kumble and Kornberg, 32 P i to cultured cells led to rapid (within minutes to 1 h) phosphate incorporation into polyP in PC12 cells while less metabolically active cells such as embryonic kidney cells and T-cells (Jurkat) showed a significantly slower or no polyP synthesis at all (Kumble and Kornberg, We investigated the kinetics of mitochondrial polyP metabolism (Seidlmayer et al., 2012a) in intact ventricular cardiomyocytes isolated from control rabbits and animals with HF combined aortic insufficiency and stenosis model (Dedkova et al., 2012b)

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(2) TREK-1 (TWIK-related potassium channel) receptor is a two-pore potassium channel recently identified as a potential target for studying and modifying animal models of depression

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