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116,117 Additionally, Smurf1 stabilizes sterol regulatory element-binding protein-1c (SREBP-1c), a key transcription factor in lipid metabolism, by preventing its ubiquitination and degradation, while BTRC promotes the proteasomal degradation of adipose triglyceride lipase

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Another critical pathway targeted in advanced melanoma involves programmed cell death protein 1 , a receptor on T cells that normally binds its ligand on peripheral tissues to maintain peripheral tolerance

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