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Furthermore, metadata from integrated reference datasets, including adult samples (GSE150728) and healthy pediatric samples (GSE135779), were used to further refine cluster annotations

Mianserin, a tetracyclic antidepressant, has been shown to inhibit tumor growth in SW480 cells in vitro and in vivo through ASCT2 inhibition ( 3.3 Glutamate dehydrogenase (GLUD/GDH) inhibitors Glutamine is enzymatically converted to glutamate by glutaminase, and further conversion of glutamate to -KG is facilitated by GLUD through oxidative deamination (Yoo et al., 2020)

Key terms explained: Oxidative stress Oxidative stress is an imbalance of free radicals and antioxidants in the body

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Also, excessive oxidant stress from pollutants can damage DNA and impair sperm function