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People with chronic kidney or liver disease can accumulate B12 due to lower detoxification function when these organs are impaired

Indeed, in more extreme cases with very aggressive inflammatory activity, a total reset of the patients immune system by autologous bone marrow transplantation has shown remarkable efficacy at stopping new relapses or MRI lesions and even modestly reversing clinical disability (Rush et al., 2019), though currently this aggressive intervention is recommended only for patients with very active inflammatory disease (Miller et al., 2021)

When cells have enough antioxidants, they can maintain their function more effectively over time

The problem the search results promise to solve is real when illness, age, or environmental load push oxidative stress higher than the body can recycle glutathione, detox capacity falls behind and inflammation climbs

VEGF and intra-organelle crosstalk 4.2.1