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However, glutathionylation is reversible through the release of GSH from cysteine residues in target proteins by thioredoxins and glutaredoxins, which are thiol oxidoreductases 138,142

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The primary site of GPS metabolism is the liver, where cytochrome P450 enzymes play a significant role in its biotransformation, resulting in the generation of diverse metabolites ( 6 Toxicity and safety Research into the acute toxicity of GPS in animal models, including mice and rats, indicates that GPS exhibits a relatively low level of acute toxicity

Overall, low return rates for TOC limited the data we have, and the small proportion of those who were prescribed a single 84-dose fill limit the power of the data we collected

1.2 10 5 SHSY-5Y cells were subjected to similar treatment as above except 1 mM MPP + (for 24 h) was used to induce ROS