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W.MurthyS

A deep insight into ferroptosis in lung disease: facts and perspectives

The tight binding of Keap1 to Nrf2 prevents the activation of Nrf2, while in the presence of external stimuli or oxidative stress, p62 protein accumulates on the mitochondrial membrane and binds to Keap1, p62-mediated Keap1 degradation to promote phosphorylation of Nrf2, translocate it into the nucleus, and then bind to anti-oxidative stress genetic elements to resistance ferroptosis [65]

SAH is a potent inhibitor of methyltransferases with a much greater affinity for these enzymes than SAMe

Hydroxypiperlongumine interacts with specific residues within the GSTP1 H-site, inhibiting its function and inducing oxidative stress