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Study Design Type: Phase 2, double-blind, randomized, placebo-controlled study Participants: 338 adults (BMI 30 or BMI 27 with a coexisting condition) Groups: Retatrutide 1 mg, 4 mg, 8 mg, 12 mg (different initial doses 2 or 4 mg) and placebo Duration: 48 weeks (plus 4 weeks follow-up) Administration: subcutaneous, 1x weekly Primary endpoint: percentage change in body weight at week 24 Secondary endpoints: change in weight at week 48, 5%, 10%, 15% weight reduction

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Although not statistically significant, LP-EVs promoted the upregulation of pathways associated with tight junctions and extracellular matrix (ECM) receptor interactions in skin tissues, changes that may also contribute to acne improvement [73, 74] (Figure S9)

24, 25 The blocking FRAA directly interferes with the binding of folate to the FR while the binding FRAA binds to the FR and triggers an antibody-mediated immune reaction

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