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(1) ROS directly attacks the mitochondria of chondrocytes, causing leakage of the electron transport chain (ETC) and further generating superoxide anion (O ), which forms a vicious cycle, inducing collapse of mitochondrial membrane potential and ATP synthesis disorder

Toussirot, E., Bereau, M., Vauchy, C

Molecular targeting of hypoxia in radiotherapy

Freischmidt, A

The results of this model reveal high BACs in mice, along with significant elevations in serum ALT and AST levels, both peaking at 9 h after administration