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Whether administration of leptin could overcome leptin resistance and exert an anti-obesity effect was tested in a placebo-controlled study with 47 obese men and women given varying doses of recombinant human leptin (0.03 mg/kg and 0.30 mg/kg, respectively) for 24 weeks and advised to eat 500 kcal less than body requirements each day

However, as healthy habits can prevent a vitamin B12 deficiency, unhealthy ones can aggravate it, such as: Smoking: smoking damages the stomach cells and difficult vitamin B12 absorption, which for a bariatric surgery patient is already reduced

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Special warnings and precautions for use: It is advisable to confirm the diagnosis of Vitamin B12 deficiency before giving hydroxocobalamin

If you have a history of pancreatitis, the risk-benefit calculation changes unfavorably unless other factors strongly favor use and careful monitoring is in place