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doi: 10.1016/j.cmet.2019.05.015

Genetic and metabolic factors of individuals

At the epigenetic level, time on ART correlated ( P 0.01) with individual GESECA scores in all highlighted pathways for at least one active epigenetic assay (ATAC, H3K27ac, and H3K4me3)

It is considered a marker for neuroinflammation because of its relationship to glial activation and BBB permeability ( Creatine is a critical regulator of energy homeostasis in the brain [e.g., (83)]