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An RCT in 72 patients with NAFLD found that NAC (600 mg twice daily) for 3 months significantly improved liver enzymes (ALT, AST) and markers of oxidative stress compared to control, though it did not significantly improve liver histology on biopsy (Khoshbaten et al., Hepat Mon, 2010) [33]

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Third, given their reliance on lipid metabolism, B1 and MZB cells are extremely susceptible to lipid peroxidation and subsequent ferroptosis secondary to ROS accumulation 142