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DeLoughery, T

This hinders the synthesis of acetyl-CoA, obstructs the tricarboxylic acid cycle (TCA), and reduces the ingestion of oxygen

Rapamycin mitigates NLRP3 inflammasome activation by inhibiting the mTOR complex 1 (mTORC1), which directly reduces A1 astrocyte formation and enhances autophagy-mediated removal of damaged cellular components, thereby attenuating neuroinflammation (304306)