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They found that in NRF-2/PGC-1 dKO mice, there is elevation of various autophagosomal markers (p62/SQSTM1, Beclin-1 and LC3B) along with the increased levels of microglia marker, Iba1 and accumulation of oxidative stress markers (4-HNE) and endoplasmic reticulum stress markers (GRP78 and ATF4

These cells interact with major histocompatibility complex class I-like molecules (MR1) and recognize ligands derived from bacteria or yeast, specific metabolites of riboflavin (vitamin B2) (103105)

Polyphenol is a compound with antioxidant and anti-inflammatory properties

SAM and SAH show pathway activity Low SAM and elevated SAH represent different biochemical barriers and should not automatically receive the same treatment