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Splenectomy is a more invasive option that is generally reserved for severe or treatment-resistant thrombocytopenia (Wang 2012)

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(PubMed) Baum MK, Miguez-Burbano MJ, Campa A, Shor-Posner G

Bronchiolitis Obliterans irreversibly develop into cirrhosis Cirrhosis Cirrhosis is a late stage of hepatic parenchymal necrosis and scarring (fibrosis) most commonly due to hepatitis C infection and alcoholic liver disease

J Nutr 121 : 12431249 Whitin JC, Tham DM, Bhamre S, Ornt DB, Scandling JD, Tune BM, Salvatierra O, Avissar N, Cohen HJ 1998 Plasma glutathione peroxidase and its relationship to renal proximal tubule function