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Given these roles, vitamin B6 deficiency can severely impact both the central and peripheral nervous systems (58)

Neuropsychopharmacology 45 , 10501058 (2020)

Completely removing eosinophils (as done in some trials with IL-5 antibodies) surprisingly doesn't cause major immunodeficiency in adults, but subtle effects exist (e.g., delayed clearance of some viruses, possible impact on tissue remodeling) (242)