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10.1126/science.286.5448.2358 Science 153 RosenE

Using SCLC NCI-H69 cells with and without HGF stimulation as the model, the screening arrays KPSS-1.3 and KPSS-2.0 together allowed detection of strong HGF-induction of specific phosphorylation sites in phosphoproteins downstream of c-MET itself, that are involved in diverse cellular regulation, including transcriptional control, cell cycle G 1 /S checkpoint, cell survival and apoptosis, cell proliferation and differentiation, stress and inflammatory response to cytokines and growth factors, as well as cytoskeletal functions