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When patients present with a high anion gap metabolic acidosis, clinicians should first exclude common, treatable causes (eg, lactic acidosis, co-ingested drug administration, and ketoacidosis)

Hepatology 58 , 762776 (2013)

1,2 Although not clinically validated or available for widespread use, measurement of holotranscobalamin, the metabolically active form of vitamin B 12 , is an emerging method of detecting deficiency

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