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CrettolS.PetrovicN.MurrayM.2010Pharmacogenetics of phase I and phase II drug metabolism.162(2010),204219,1381-6128 25

Glutathione supports this process by protecting mitochondria from damage and ensuring efficient energy production

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COXs are abundantly expressed in neurons and microglia across various animal species ( in vivo and in vitro experimental showed that tumor necrosis factor- (TNF-)-mediated BBB breakdown is linked to COXs up-regulation the expression and activity of matrix metalloproteinases (MMPs) (Sugimoto et al., 2009)