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Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells

The cytosolic p53 inhibits the formation of autophagic vacuoles 68 by interaction with FIP200 (FAK (focal adhesion kinase) family kinase-interacting protein of 200 kDa), whereas nuclear p53 acts as a transcriptional factor of genes implied in autophagy regulation