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These pathways do not operate in isolation

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(PubMed) Khalili M, Azimi A, Izadi V, et al

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Effects of p21Cip1/Waf1 at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

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Kojic acid is faster and more aggressive, while alpha arbutin offers steady results with minimal irritation

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