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However, if saturated fatty acids accumulate in excess in cells, they become toxic and induce the generation of ROS, endoplasmic reticulum stress and NLRP3 inflammasome activation, which are all associated with a pro-inflammatory macrophage phenotype (Legrand-Poels et al., 2014)

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Therefore, more studies are needed to identify microbiome peptides that have homologous sequences with retinal antigens (including IRBP and retinal S-antigen) and melanocyte antigens (target antigens of VKH disease, including tyrosinase and gp100)

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