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Noncancerous nodules may be managed through: Watchful waiting with regular monitoring Thyroid hormone therapy to suppress nodule growth Radioactive iodine, antithyroid medications, or beta blockers for nodules causing hyperthyroidism Cancerous thyroid nodules, large nodules causing compressive symptoms, or nodules with concerning features typically require surgical removal

Traumatic endplate damage also causes necrotic cell death 13 and the release of intracellular contents, including many pro-inflammatory compounds known as damage-associated molecular patterns (DAMPs)

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