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Ultimately, enhanced targeting of inflammation may produce improvements in functional status and wellbeing beyond the reach of current therapeutic modalities

In addition, treatment with 5-FU or AZ628 led to an increase in the intracellular levels of ferrous iron, as measured by confocal and flow cytometry of FeRhoNox-1 staining ( Figures 4E, F , and Supplementary Figures S3C, D )