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This evidence provides a connection between impaired energy metabolism and neurodegeneration in PD and HD and suggests that stimulating mitochondrial biogenesis by PGC-1 might be a promising strategy for the prevention of PD

Geographically, Asia-Pacific is projected to be the fastest-growing region, fueled by rising disposable incomes, urbanization, and the rapid adoption of health supplements in countries such as China, India, and Southeast Asian nations

Understanding these mechanisms elucidates the biochemical basis of NO-induced neurotoxicity and its clinical manifestations