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doi:10.1016/j.schres.2005.02.010

MR-Egger-SIMEX can provide estimation with adjustment for dilution of the MR-Egger estimate using the simulation extrapolation (SIMEX) method, as a supplementary tool for MR-Egger when I 2 GX 0.05)

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The only discernible difference you're likely to notice between Oklahoma Smokes and traditional brands is that they burn a little faster due to their additive-free paper