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ALP can catalyze the conversion of inactive substrates into active reducing products that can induce the metallization on the pre-prepared metal NPs, leading to an obvious color change [147]

[DOI] [PubMed] [Google Scholar] 64.Guenther B.D., Sheppard C.A., Tran P., Rozen R., Matthews R.G., Ludwig M.L

The FDA granted the Breakthrough Therapy designation based on these data, and the phase III IMBRAVE 150 trial was initiated

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An internal enzyme known as glutamine synthetase drives this process by taking glutamate and ammonia both naturally available in muscle tissue and assembling them in a reaction fuelled by adenosine triphosphate (ATP)