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revealed that prolonged intake (90 days) of high concentrations of green tea catechins (5%) brought about hepatotoxic effects in male rats by the increased levels of ALT and AST 48 , which could suggest that the use isolated or pure polyphenols could be detrimental to the functioning of these organs

Electrophilic natural products as drug discovery tools

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Libraries for RNA-seq were made using a TruSeq Stranded mRNA Sample Preparation Kit (Illumina) with 500 ng RNA

116 Additionally, lactylation of domain-containing type I (DCBLD1) stabilizes its expression to activate the downstream pentose phosphate pathway (PPP) in cervical cancer cells