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Published mechanisms include upregulation of growth hormone receptor expression, promotion of angiogenesis via VEGF pathway activation, modulation of the nitric oxide system, and interaction with the dopaminergic and serotonergic systems in neurological models

Additionally, researchers did not account for other medications or addictions (e.g., alcohol) which may cause PD-like symptoms

Key compounds in milk thistle, like silymarin and silybin, boost liver enzyme activity and help reduce oxidative stress

To avoid these limitations, targeted activation of the endogenous cellular antioxidant machinery has emerged as an alternative therapeutic strategy for the reduction of oxidative stress (Davis and Pennypacker 2017