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In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy

In a retrospective cohort study of 360 MLH1- or MSH2 mutation carriers with the primary aim of determining whether cigarette smoking would alter CRC risk, alcohol use information was available in 271 carriers, of whom 83 (30.6%) were classified as non-users

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Their removal from Category 2 is a massive relief to the functional medicine community, but it requires careful clinical navigation moving forward

However, only a small number of bacteria, including Listeria monocytogenes, Shigella flexneri, Burkholderia pseudomallei, Francisella tularensis and Rickettsia spp., can gain access to and proliferate within the host cell cytosol