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& Fowler, S

In patients with PAH, chemokines secreted locally by pulmonary vessels recruit B cells, which recognize self-antigens via B cell receptors and receive co-stimulatory signals from follicular helper T cells (Tfh) (IL-21), Th2 cells (IL-4/IL-6/IL-13), and mast cell cytokines

Both effects are more prominent in hybrid A 42 -fibrils than in A 40 -hybrids where they are counteracted by the opposite arrangement and orientation of the characteristic salt bridge D23-K28 salt bridge and the different magnitude and orientation of -strands twists

Although the anti-oxidant property of Apo2 appears to protect against the development of AD possibly via minimizing A aggregation, patients carrying Apo4 alleles show increased deposition of A [141]

Kluft, Th