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Osteocytesthe most abundant bone cells entombed in the bone matrixare also affected, as indicated by a reduction in osteocyte density (number of osteocyte-occupied lacunae per unit area) in diabetic rats [44]

Fan G, Chen S, Zhang Q, Yu N, Shen Z, Liu Z, et al

A phase II trial (Ocera Therapeutics (2014) showed a comparable efficacy to that of lactulose in patients with mHE, with fewer side effects, although more studies are required for the further development of this treatment

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