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The finding that TICs, rather than differentiated tumor cells, grow in 3D gels offers a unique opportunity to unveil TIC-specific signaling pathways and therapeutic targets common to various cancer types

The holistic effect of all extrinsic factors accounting for the phase transformation is to shield or neutralize the charges at the N or C terminal ends, as this has been also confirmed by specific site directed mutations of key residues of the protein (Pancoe et al., 2022)

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