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IFN-responsive genes were hypomethylated to a greater extent in patients with renal involvement, and the authors highlighted the IFN regulatory factor family member gene IRF7, which was demethylated only in SLE patients with renal disease

The data presented here suggest that Nle1-AngIV and Dihexa increase miniature synaptic activity by increasing dendritic spine densities and altering the morphological phenotype of postsynaptic spines in-vitro and may represent the mechanism that underlies facilitated learning observed AngIV analogues (Wright, Stubley et al

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doi: 10.1038/s41586-023-06255-6 44 DollSFreitasFPShahRAldrovandiMDa SilvaMCIngoldIet al

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