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It is unclear precisely what the changes in electrophoretic mobility represent for these various forms of phospho-Tau, but most likely they reflect changes in phosphorylation at other sites on the molecule

Bacteriostatic Water Labs solves that

J Neurochem 24(5):881884 Muir D, Berl S, Clarke DD (1986) Acetate and fluoroacetate as possible markers for glial metabolism in vivo

That said, human safety data currently consists of only three small studies with no randomized controlled trials, and the longest follow-up spans just 6 to 12 months