melatonin glutathione peroxidase Alternative modes of action in target cells. Melatonin can Understanding the Mechanism of Action

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The caveat of the research is that glutamate act on its different receptors that might be expressed on the human melanoma cells used in the study, therefore, the mentioned observation is a net effect from different receptor activation

Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease

And then free radicals

(b) N-terminal part of protein alignment (Jalview) showing the presence or absence of N-terminal extensions indicative of putative N-terminal targeting peptides