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Using these approaches to study the transport of molecules into the growth plate may ultimately provide a better understanding of how larger signaling molecules such as FGFs (FGF2, 18kDA

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These data, along with a crystal structure analysis of LSN3441732 bound simultaneously to two K IV 8 domains, show that multiple apo(a) K IV domains can be engaged simultaneously, which leads to an improvement in binding affinity and Lp(a) inhibition potency (Extended Data Fig

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