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Neurological deficits severely affect patients quality of life and impose a significant burden on healthcare systems globally (Feigin et al

Nature 617 , 386394 (2023)

J Infect (2020) 81:5771

Recent statistics show that the incidence of AKI in general hospitalized patients is approximately 1015%, while it can exceed 50% in intensive care units ( In most cases, the integrity of renal parenchyma is compromised by renal tubular dysfunction caused by low perfusion or by direct damage to renal interstitial tissues and cellular functions by toxins ( This review examines the sources of oxidative stress in AKI, the mechanisms by which oxidative stress-induced ER stress contributes to cell death through autophagy and apoptosis, and discusses the potential of antioxidants to alleviate these processes in the treatment of AKI

Braun JA, Herrmann AL, Blase JI, Frensemeier K, Bulkescher J, Scheffner M et al (2019) Effects of the antifungal agent ciclopirox in HPV-positive cancer cells: repression of viralE6/E7oncogene expression and induction of senescence and apoptosis