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If the hospital's cost of furnishing a service exceeds both the multiplier threshold and the fixed-dollar threshold, the outlier payment is calculated as 50 percent of the amount by which the hospital's cost of furnishing the service exceeds 1.75 times the APC payment amount

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In contrast, intercurrent events such as smoking cessation or switching to another approved weight-loss medication would only need to be accounted for in trials in which these phenomena are expected to have a substantial effect on the endpoint in question, for example, if the intercurrent event is common, or if it occurs at different rates between active and placebo arms

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