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To demonstrate that suppression of p70S6K protein and pNPM1 by RSL3 is GPX4 inhibition-specific in PTC cells, we treated K1 cells with RSL3 (3 M) in the presence of ferrostatin-1 (5 M), an effective inhibitor of ferroptosis and analyzed by Western blotting

doi: 10.1016/j.ajpath.2012.01.019

Additionally, PCOS often encompasses a variety of metabolic disorders, such as insulin resistance, obesity, type 2 diabetes (T2D), hypertension, and cardiovascular diseases 8

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In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41