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Zhang T, Zhang M, Cui S, Liang W, Jia Z, Guo F, Ou W, Wu Y, Zhang S (2023) The core of maintaining neuropathic pain: crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord)

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Excess iron is stored in plasma ferritin in an oxidationreduction-inactive state, and a small amount of Fe 2+ results in an unstable iron pool

However, recent results from STEADY-PD III (NCT02168842, Table 2), a 36-month, multicenter, randomized, parallel-group, placebo-controlled trial (Investigators 2020) demonstrated no significant clinical effect of isradipine in progression of early-stage PD, measured as the change of MDS-UPDRS part I to III score in the ON medication state, from baseline to 36 months