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doi:10.3945/ajcn.110.004945 Rizza S, Muniyappa R, Iantorno M, et al

The metabolic pathways and corresponding enzymes are organized around the TCA cycle at the center, branching out to include amino acid metabolism, purine metabolism, and the glutathione cycle, highlighting the interconnectivity and complex response to the oxidative stress induced by the absence of GR

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As expected, compared with control cells, GPx1-shRNA-expressing cells in DMEM or glucose-free medium exhibited increased levels of LC3-II protein (Fig