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doi: 10.1074/jbc.M010793200 22 ConradMPrattDA

Chain reaction in cells may be driving low energy in ME/CFS patients In a world first, Griffith University researchers have identified a key immune cell dysfunction in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), offering new clues on the condition

In one program, a separate NNMT inhibitor reduced 1-methylnicotinamide levels and improved insulin sensitivity and glucose tolerance in DIO mice, with these effects absent in NNMT-knockout animals

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Methodologically, a lack of standardization among various types of assays (e.g., enzymic recycling, HPLC, LCMS/MS) is a source of high inter-laboratory variation and conflicting results